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Therapie

Semaglutide and tirzepatide — how they differ

Two active substances, two mechanisms. What they do in the body, how they are given, and who decides.

by instafit Team

Editorial team · 7 min Reading time

Semaglutide mimics the body’s own GLP-1 hormone. It slows gastric emptying and acts on satiety regulation in the brain. Depending on the preparation and dose it is approved for blood-sugar control or for treating obesity.

Tirzepatide acts on two receptors — GLP-1 and, in addition, GIP. Both are injected under the skin once a week.

Which substance and which preparation are right for you depends on your BMI, comorbidities, tolerability and the conditions for reimbursement. That decision belongs to your physician, in a personal conversation — not to a website. In Switzerland, prescription-only medicines may not be named in advertising aimed at the public, so we name only the active substances.

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